Development of Label-free Raman Assessment of Metastatic Bone

POSTER

Abstract

Bone metastasis has a significant pathological impact in the form of bone fracture risks that are caused by chronic bone loss and degeneration. The goal of this study is to evaluate bone quality by Raman spectroscopy, which enables assessment and differentiation between non-cancerous and cancerous specimens. Besides spectral analysis of bone constituents and of the key biomarker in cancer identification, namely, the phosphate constituent, we also present representative confocal Raman maps of their distributions. The statistically significant number of spectra considered in this study validates the accuracy of our analysis from both perspectives: that of spectroscopic measurements and that of a statistical approach.

Authors

  • Matthew Alonzo

    • Department of Physics, University of Texas at El Paso, El Paso, TX

  • Chao Qiu

    • Department of Physics, University of Texas at El Paso, El Paso, TX

  • Avudaiappan Maran

    • Department of Orthopedics, Mayo Clinic, Rochester, MN

  • Michael Yaszemski

    • Department of Orthopedics, Mayo Clinic, Rochester, MN

  • John Ciubuc

    • Department of Physics, University of Texas at El Paso, El Paso, TX

  • Marian Manciu

    • Department of Physics, Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX

  • Felicia Manciu

    • Department of Physics, Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX
    • Department of Physics, Border Biomedical Research Center, The University of Texas at El Paso
    • Department of Physics, Border Biomedical Research Center, University of Texas at El Paso