Statistical machine learning for learning representations of embryonic development

During embryonic development, single cells read in local information from their environments and use this information to move, divide and specialize. As a result, the environments themselves change. However, it remains unclear how gene expression programs interact with cell morphology and mechanical forces to orchestrate organogenesis in early embryos. Recent advances in single cell techniques and in toto imaging enable unique venues in exploring this link between genomics and biophysics, which dynamically maps cells to organisms.

In this talk, I will describe statistical machine learning frameworks aimed at understanding how tissue level mechanical and morphometric information impact gene expression patterns in spatio-temporal contexts. We use these tools to understand boundary formation in the early development of mouse embryos and to align data from light sheet recordings of pre-gastrulation development