In situ single-cell mechanics of mouse preimplantation embryos

ORAL

Abstract

The first lineage segregation and self-organization of mammalian embryos take place during the transition from zygote towards blastocyst, where large mechanical deformations can be observed. Yet the role of mechanics in this process is not clear, especially due to the lack of approaches to probe mechanical properties in situ. In this work, we use microrheology to monitor the evolution of mechanical properties of mouse preimplantation embryos at single-cell resolution.

* We would like to acknowledge the support from NIH (1R01GM140108).

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Presenters

  • Haiqian Yang

    Massachusetts Institute of Technology MIT

Authors

  • Haiqian Yang

    Massachusetts Institute of Technology MIT

  • Ehsan Habibi

    Broad Institute of MIT and Harvard

  • Anubhav Sinha

    Broad Institute of MIT and Harvard

  • Aviv Regev

    Broad Institute of MIT and Harvard

  • Fei Chen

    Broad Institute of MIT and Harvard

  • Ming Guo

    Massachusetts Institute of Technology MIT, MIT