DNA-Associated Biomolecular Condensates

Presentations

• The interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening

  ORAL · Invited

  March 18, 2025, 8:00 AM – March 18, 2025, 8:36 AM

  Publication: D.S. Banerjee+, T. Chigumira+, R.M. Lackner, J.C. Kratz, D.M. Chenoweth, S. Banerjee*, H. Zhang*. Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening. bioRxiv: https://doi.org/10.1101/2024.05.07.593010.

  Presenters

  • Huaiying Zhang

    • Carnegie Mellon University

  Authors

  • Huaiying Zhang

    • Carnegie Mellon University

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• Physical mechanisms underlying spatial targeting of chromatin-associated biomolecular condensates

  ORAL

  March 18, 2025, 8:36 AM – March 18, 2025, 8:48 AM

  Publication: [1] Strom, Amy R., Jorine M. Eeftens, Yury Polyachenko, Claire J. Weaver, Hans-Frederick Watanabe, Dan Bracha, Natalia D. Orlovsky, Chanelle C. Jumper, William M. Jacobs, and Clifford P. Brangwynne. "Interplay of condensation and chromatin binding underlies BRD4 targeting." Molecular biology of the cell 35, no. 6 (2024): ar88.; https://doi.org/10.1091/mbc.E24-01-0046

  Presenters

  • Yury Anatolievich Polyachenko

    • Princeton University

  Authors

  • Yury Anatolievich Polyachenko

    • Princeton University

  • Hans-Frederick Watanabe

    • Princeton University

  • Alexey Korolev

    • Princeton University

  • William M Jacobs

    • Princeton University

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• Active RNA synthesis patterns nuclear condensates

  ORAL

  March 18, 2025, 8:48 AM – March 18, 2025, 9:00 AM

  Publication: Active RNA synthesis patterns nuclear condensates. Salman F. Banani, Andriy Goychuk, Pradeep Natarajan, Ming M. Zheng, Giuseppe Dall'Agnese, Jonathan E. Henninger, Mehran Kardar, Richard A. Young, Arup K. Chakraborty. bioRxiv 2024.10.12.614958; doi: https://doi.org/10.1101/2024.10.12.614958

  Presenters

  • Andriy Goychuk

    • Massachusetts Institute of Technology

  Authors

  • Andriy Goychuk

    • Massachusetts Institute of Technology

  • Pradeep Natarajan

    • Massachusetts Institute of Technology

  • Salman F Banani

    • University of Chicago

  • Ming M Zheng

    • Whitehead Institute

  • Giuseppe Dall'Agnese

    • Whitehead Institute

  • Jonathan E Henninger

    • Carnegie Mellon University

  • Mehran Kardar

    • Massachusetts Institute of Technology

  • Richard A Young

    • Whitehead Institute

  • Arup K Chakraborty

    • Massachusetts Institute of Technology

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• Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates

  ORAL

  March 18, 2025, 9:00 AM – March 18, 2025, 9:12 AM

  Publication: Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates
  Lingyu Meng, Sheng Mao, Jie Lin
  Proceedings of the National Academy of Sciences (PNAS), 121 (12), e2316610121, 2024

  Presenters

  • Jie Lin

    • Peking University

  Authors

  • Jie Lin

    • Peking University

  • Lingyu Meng

    • Peking University

  • Sheng Mao

    • Peking University

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• Computational Studies of Liquid-Liquid Phase Separation within Elastic and Inelastic Networks

  ORAL

  March 18, 2025, 9:12 AM – March 18, 2025, 9:24 AM

  Presenters

  • Ji Qi

    • Princeton University

  Authors

  • Ji Qi

    • Princeton University

  • Mikko P Haataja

    • Princeton University

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• Brownian Dynamics Simulation of Dps:DNA Condensate Formation in Starved E. Coli

  ORAL

  March 18, 2025, 9:24 AM – March 18, 2025, 9:36 AM

  Presenters

  • Alberto Alonso

    • Rochester Institute of Technology

  Authors

  • Alberto Alonso

    • Rochester Institute of Technology

  • Lauren Melcher

    • Rochester Institute of Technology

  • Elio A Abbondanzieri

    • University of Rochester

  • Anne S Meyer

    • University of Rochester

  • Moumita Das

    • Rochester Institute of Technology

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• Histone tail-DNA condensates show acetylation-dependent viscoelastic coupling to single DNA mechanics

  ORAL

  March 18, 2025, 9:36 AM – March 18, 2025, 9:48 AM

  Presenters

  • Priya R Banerjee

    • The State University of New York at Buffalo

  Authors

  • Priya R Banerjee

    • The State University of New York at Buffalo

  • Davit Potoyan

    • Iowa State University

  • Emma Morrison

    • Medical College of Wisconsin

  • Ritika Gupta

    • The State University of New York at Buffalo

  • Anurag Singh

    • The State University of New York at Buffalo

  • Erin Hammonds

    • Medical College of Wisconsin

  • Joseph Basalla

    • The State University of New York at Buffalo

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• A thermodynamic study of condensate formation in a mixture of DNA-binding protein from starved cells (Dps) and DNA

  ORAL

  March 18, 2025, 9:48 AM – March 18, 2025, 10:00 AM

  Presenters

  • Soumik Mitra

    • Rochester Institute of Technology

  Authors

  • Soumik Mitra

    • Rochester Institute of Technology

  • Luke Studt

    • Rochester Institute of Technology

  • Elio A Abbondanzieri

    • University of Rochester

  • Anne S Meyer

    • University of Rochester

  • Moumita Das

    • Rochester Institute of Technology

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• Elastocapillary interaction between condensate and chromatin

  ORAL

  March 18, 2025, 10:00 AM – March 18, 2025, 10:12 AM

  Presenters

  • Hongbo Zhao

    • Princeton University
    • University of California San Diego
    • University of California, San Diego

  Authors

  • Hongbo Zhao

    • Princeton University
    • University of California San Diego
    • University of California, San Diego

  • Amy Strom

    • Princeton University

  • Mikko P Haataja

    • Princeton University

  • Andrej Kosmrlj

    • Princeton University

  • Cliff Brangwynne

    • Princeton University

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• Single molecule studies of chromatin structure in transcription condensates

  ORAL

  March 18, 2025, 10:12 AM – March 18, 2025, 10:24 AM

  Presenters

  • Jan Spille

    • University of Illinois Chicago

  Authors

  • Jan Spille

    • University of Illinois Chicago

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• Measuring Chromatin-nucleolus Interactions in Living Cells

  ORAL

  March 18, 2025, 10:24 AM – March 18, 2025, 10:36 AM

  Presenters

  • Yu-Chieh Chung

    • The Ohio State University

  Authors

  • Yu-Chieh Chung

    • The Ohio State University

  • Li-Chun Tu

    • The Ohio State University

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• Cluster size determines morphology of transcription factories in human cells

  ORAL

  March 18, 2025, 10:36 AM – March 18, 2025, 10:48 AM

  Presenters

  • Giuseppe Negro

    • University of Edinburgh

  Authors

  • Giuseppe Negro

    • University of Edinburgh

  • Davide Marenduzzo

    • University of Edinburgh

  • Massimiliano Semeraro

    • University of Bari

  • Giada Forte

    • University of Edinburgh

  • Giuseppe Gonnella

    • University of Bari

  • Antonio Suma

    • Università degli studi di Bari

  • Peter R Cook

    • University of Oxford

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• Limits to concentration sensing in inhomogeneous environments

  ORAL

  March 18, 2025, 10:48 AM – March 18, 2025, 11:00 AM

  Presenters

  • Nicholas Lawson

    • Princeton University

  Authors

  • Nicholas Lawson

    • Princeton University

  • William S Bialek

    • Princeton University

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